Li Lingbing, Tan Yebang
Department of Pharmaceutics, Shandong University, Jinan 250012.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Mar;20(1):17-21.
The mechanism of drug release from swellable polymer was studied. The model which can explain the drug release from glassy polymer was developed by coupling drug diffusion equation and solvent diffusion equation. The effect of viscoelastic stress of polymer was also considered. The Deborah number and swelling interface number were used to describe the mechanism of drug release, especially relax controlled mechanism.
研究了药物从可溶胀聚合物中的释放机制。通过将药物扩散方程和溶剂扩散方程耦合，建立了能够解释药物从玻璃态聚合物中释放的模型。同时还考虑了聚合物粘弹性应力的影响。采用德博拉数和溶胀界面数来描述药物释放机制，特别是松弛控制机制。
