Liu Zhimin, Jiang Lili, Yang Bin, Liao Dianying
Laboratory of Surgical Department, West China Hospital, Sichuan University, Chengdu 610041.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Mar;20(1):68-70.
To investigate the relationship of the expression of vascular endothelial growth factor (VEGF) and C-myc with the occurrence, development and metastasis of gallbladder carcinoma, the expression levels of VEGF and C-myc in gallbladder carcinoma tissue (n = 30) and in normal gallbladder tissue (n = 20) were examined by immunochemistry. Results show that the positive rates of VEGF and C-myc in gallbladder carcinoma tissue were 80% and 63.3% respectively, and 45% and 25% respectively in normal gallbladder tissue. The positive rates of VEGF and C-myc were significantly higher in gallbladder carcinoma than in normal gallbladder tissue. The expression of VEGF and C-myc in gallbladder carcinoma related to the metastasis of gallbladder carcinoma. VEGF and C-myc play important roles in the occurrence, development and metastasis of gallbladder carcinoma.
为探讨血管内皮生长因子（VEGF）和C-myc的表达与胆囊癌发生、发展及转移的关系，采用免疫化学方法检测30例胆囊癌组织及20例正常胆囊组织中VEGF和C-myc的表达水平。结果显示，胆囊癌组织中VEGF和C-myc的阳性率分别为80%和63.3%，正常胆囊组织中分别为45%和25%。胆囊癌组织中VEGF和C-myc的阳性率显著高于正常胆囊组织。胆囊癌中VEGF和C-myc的表达与胆囊癌转移有关。VEGF和C-myc在胆囊癌的发生、发展及转移中起重要作用。
