Worst P K, Boukamp H K
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Oct 27;84(2):97-103. doi: 10.1007/BF00304036.
Skin autografting or a single painting with the cocarcinogen TPA was used to induce epidermal hyperplasia in the back skin of C3H mice. Initiation by intragastric application of the carcinogen DMBA during this state of hyperplasia and subsequent promotion by repeated application of the cocarcinogen TPA led to decreased papilloma-formation, as compared to mice of a control group which had not been pretreated before initiation. Reports by others referring to increased susceptibility of replicating epidermal cells to the effect of initiation thus cannot be confirmed. The reduction of papilloma-formation can most probably be ascribed to effects of local inflammation, either preferentially but unspecifically damaging initiated cells, or facilitating a specific immune response against tumor-associated transplantation antigens of prospective tumor cells.
采用自体皮肤移植或单次涂抹促癌剂佛波酯（TPA）的方法，诱导C3H小鼠背部皮肤表皮增生。在此增生状态下，通过胃内给予致癌物二甲基苯并蒽（DMBA）启动致癌过程，随后反复涂抹促癌剂TPA进行促癌，结果显示，与启动前未进行预处理的对照组小鼠相比，乳头状瘤形成减少。因此，其他人关于复制期表皮细胞对启动效应敏感性增加的报道无法得到证实。乳头状瘤形成减少很可能归因于局部炎症的影响，这种炎症要么优先但非特异性地损伤启动细胞，要么促进针对潜在肿瘤细胞的肿瘤相关移植抗原的特异性免疫反应。
