Zhu Hong-Hu, Xu Kai-Lin
Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Apr;11(2):208-12.
As lentiviral vector holds the characteristics of higher transfection to non-dividing cells, larger capacity of transfer gene fragments, long-term expression of therapeutic gene and lower rate of immunological response, therefore it becomes potential viral vector in gene therapy. Improvements of lentiviral vector, human immunodeficiency virus type-I as example, and its application in gene transfer for gene therapy of hematological diseases are emphasized in this review.
由于慢病毒载体具有对非分裂细胞转染效率高、转移基因片段容量大、治疗基因长期表达以及免疫反应率低等特点，因此它成为基因治疗中潜在的病毒载体。本文着重综述了以I型人类免疫缺陷病毒为例的慢病毒载体的改进及其在血液系统疾病基因治疗的基因转移中的应用。
