Chua Karen S G, Kong K H
Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore, Republic of Singapore.
Brain Inj. 2003 Jun;17(6):535-44. doi: 10.1080/0269905021000010104.
Acquired Heterotopic Ossification (HO) has been well described in the literature as a recognized complication following spinal cord injury, traumatic brain injury and joint arthroplasty. Commonly, large proximal limb joints are affected. The underlying mechanisms for ectopic bone formation remain poorly elucidated. Post-stroke hemiplegia as a cause of neurogenic HO is rare, and no published reports of HO occurring after anoxic brain injury in adults have been documented. This study reports two unusual cases of acquired HO: (1) Polyarticular HO involving the ankle joint in a 24-year-old Chinese female who suffered severe anoxic encephalopathy following near drowning which resulted in persistent vegetative state; and (2) Elbow HO in chronic post-stroke hemiplegia occurring as a complication of alternative therapy following repeated forceful manipulation by a traditional practitioner in a 46 year-old male.
获得性异位骨化（HO）在文献中已有充分描述，是脊髓损伤、创伤性脑损伤和关节置换术后公认的并发症。通常，上肢近端大关节会受到影响。异位骨形成的潜在机制仍未完全阐明。中风后偏瘫作为神经源性HO的病因较为罕见，且尚无关于成人缺氧性脑损伤后发生HO的公开报道。本研究报告了两例不寻常的获得性HO病例：（1）一名24岁中国女性，因溺水后严重缺氧性脑病导致持续植物状态，出现累及踝关节的多关节HO；（2）一名46岁男性，因传统治疗师反复强力手法操作后替代疗法的并发症，在慢性中风后偏瘫中出现肘部HO。
