Szulczyk P, Trzebski A, Grebski J
Acta Physiol Pol. 1976 Jan-Feb;27(1):1-8.
A transient rise of intracranial pressure in cats under chloralose-urethane anaesthesia increased the activity of the sympathetic vertebral nerve, cardiac nerve and in the first phase phrenic nerve. If the vagus nerves were intact this rise in sympathetic activity was associated with bradycardia. These effects developed with a delay, as a rule after abatement of the transient intracranial pressure rise. The authors suggest that Cushing's reaction is caused by medullary ischaemia and development of local metabolic acidosis activating simultaneously the sympathetic and parasympathetic neurons in the medulla oblongata.
在氯醛糖-乌拉坦麻醉下，猫颅内压的短暂升高会增加交感神经、心神经以及第一阶段膈神经的活动。如果迷走神经完整，交感神经活动的这种增加与心动过缓有关。这些效应会延迟出现，通常在短暂颅内压升高消退之后。作者认为，库欣反应是由延髓缺血和局部代谢性酸中毒的发展引起的，同时激活了延髓中的交感和副交感神经元。
