De Raeve H, Schoonooghe P, Wibowo R, Van Marck E, Goossens A
Department of Surgical Pathology, University Hospital Antwerp, Edegem, Belgium.
Pathol Res Pract. 2003;199(2):113-7. doi: 10.1078/0344-0338-00363.
A 45-year old man presented with a slow-growing, unilateral beige testicular mass, with a diameter of 4 cm. The testosterone, FSH, LH, estradiol and betahCG serum levels were within normal limits, and there were no associated hormonal syndromes. The patient was treated with inguinal orchidectomy. Microscopically, the tumor was composed of nests of cells with large eosinophilic, slightly granular cytoplasm. There was only a mild degree of atypia and no mitotic activity. The tumor extended into the rete testis. There were intratumoral calcifications, and in the vicinity of the tumor, there was intratubular growth. Although this case is histologically similar to the three previously reported cases of clinically benign large cell calcifying Sertoli cell tumor of the testis with rete testis involvement, the current patient developed right sided para-aortic lymph node metastases 18 months after the initial diagnosis.
一名45岁男性患者出现一个生长缓慢的单侧米色睾丸肿块，直径为4厘米。睾酮、促卵泡生成素、促黄体生成素、雌二醇和β人绒毛膜促性腺激素血清水平均在正常范围内，且无相关激素综合征。该患者接受了腹股沟睾丸切除术。显微镜下，肿瘤由巢状细胞组成，细胞具有大的嗜酸性、略呈颗粒状的细胞质。仅有轻度异型性，无有丝分裂活性。肿瘤延伸至睾丸网。肿瘤内有钙化，且在肿瘤附近有小管内生长。尽管该病例在组织学上与之前报道的3例累及睾丸网的临床良性大细胞钙化性睾丸支持细胞瘤病例相似，但该患者在初始诊断18个月后出现了右侧腹主动脉旁淋巴结转移。
