特定单链DNA结合因子对BRCA1转录的调控。
Regulation of BRCA1 transcription by specific single-stranded DNA binding factors.
作者信息
Thakur Sanjay, Nakamura Tatsuya, Calin George, Russo Andrea, Tamburrino Joseph F, Shimizu Masayoshi, Baldassarre Gustavo, Battista Sabrina, Fusco Alfredo, Wassell Richard P, Dubois Garret, Alder Hansjuerg, Croce Carlo M
机构信息
Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA.
出版信息
Mol Cell Biol. 2003 Jun;23(11):3774-87. doi: 10.1128/MCB.23.11.3774-3787.2003.
Abstract
Since the majority of high-grade breast cancers express reduced levels of BRCA1 mRNA, we investigated the factors regulating BRCA1 transcription. Factors with specific affinity for the previously identified positive regulatory region (PRR) in the BRCA1 promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series of related factors with affinity for the sense strand of PRR. A subset of the identified factors activated the BRCA1 promoter. Identification of these families of proteins regulating the BRCA1 promoter represents an important step in the comprehension of the mechanisms responsible for breast cancer development.
摘要
由于大多数高级别乳腺癌中BRCA1 mRNA的表达水平降低，我们研究了调节BRCA1转录的因素。从全细胞提取物中纯化出对BRCA1启动子中先前鉴定的正调控区（PRR）具有特异性亲和力的因子。鉴定出的蛋白质包括复制蛋白A和一系列对PRR有义链具有亲和力的相关因子。鉴定出的部分因子可激活BRCA1启动子。这些调节BRCA1启动子的蛋白质家族的鉴定是理解乳腺癌发生机制的重要一步。
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