Kong Wencheng, Yin Guang, Zheng Sixin, Liu Xinchun, Zhu Akao, Yu Panpan, Zhang Jian, Shan Yuqiang, Ying Rongchao, Jin Huicheng
Department of Gastroenterological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China.
Genes Dis. 2021 Aug 21;9(5):1269-1280. doi: 10.1016/j.gendis.2021.07.006. eCollection 2022 Sep.
Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR-protein and HOTAIR-DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies.
胃癌是全球最早出现的恶性肿瘤之一，每年有大量的人死于这种疾病。许多遗传和表观遗传风险因素已被确定，它们在胃癌中起着重要作用。HOTAIR是一种有效的表观遗传因子，被称为长链非编码RNA（lncRNA）。据描述，HOTAIR通过与许多因子相互作用，在生化和细胞过程中具有生物学功能，从而导致基因组稳定性、增殖、存活、侵袭、迁移、转移和耐药性。在本文中，我们综述了HOTAIR调控的分子机制的预后价值及其在胃癌发生发展中的作用，而阐明HOTAIR与蛋白质及HOTAIR与DNA的相互作用有助于识别癌症过程，从而开发潜在的治疗策略。
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