Boyle William J, Simonet W Scott, Lacey David L
Protein Pathways, Inc., Woodland Hills, California 91367, USA.
Nature. 2003 May 15;423(6937):337-42. doi: 10.1038/nature01658.
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss.
破骨细胞是源自单核细胞/巨噬细胞造血谱系的特化细胞，它们发育并附着于骨基质，然后分泌酸和裂解酶，在一个特殊的细胞外隔室中对其进行降解。破骨细胞中RANK信号通路的发现，为破骨细胞生成和骨吸收激活的机制，以及激素信号如何影响骨骼结构和骨量提供了深入了解。对该信号通路的进一步研究，正在为开发治疗骨质疏松症和其他骨质流失疾病的疗法提供分子基础。
