用于研究多肽-α- N-乙酰半乳糖胺转移酶的新型UDP-N-乙酰半乳糖胺类似物的合成与生物学评价
Synthesis and biological evaluation of new UDP-GalNAc analogues for the study of polypeptide-alpha-GalNAc-transferases.
作者信息
Busca Patricia, Piller Véronique, Piller Friedrich, Martin Olivier R
机构信息
Institut de Chimie Organique et Analytique, Université d'Orléans, BP 6759, 45067 Orléans, France.
出版信息
Bioorg Med Chem Lett. 2003 Jun 2;13(11):1853-6. doi: 10.1016/s0960-894x(03)00287-7.
Abstract
A series of three O-methylated UDP-GalNAc analogues have been synthesised using a divergent strategy from a 3,6-di-O-pivaloyl GlcNAc derivative. The biological activity of these probes toward polypeptide-alpha-GalNAc-transferase T1 has been investigated. This study shows that this glycosyltransferase exhibits a very high substrate specificity.
摘要
使用一种从3,6-二-O-新戊酰基GlcNAc衍生物出发的发散策略合成了一系列三种O-甲基化的UDP-GalNAc类似物。已经研究了这些探针对多肽-α-GalNAc转移酶T1的生物活性。这项研究表明，这种糖基转移酶表现出非常高的底物特异性。
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