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危重症患儿气管内吸痰时使用或不使用等渗氯化钠溶液滴注。

Endotracheal suctioning with or without instillation of isotonic sodium chloride solution in critically ill children.

作者信息

Ridling Debra A, Martin Lynn D, Bratton Susan L

机构信息

Children's Hospital and Regional Medical Center, Seattle, Wash., USA.

出版信息

Am J Crit Care. 2003 May;12(3):212-9.

Abstract

BACKGROUND

Instillation of isotonic sodium chloride solution for endotracheal tube suctioning is controversial. Research has focused on the effect of such instillation in adults; no studies in children have been published.

OBJECTIVES

(1) To describe differences in oxygen saturation depending on whether or not isotonic sodium chloride solution is instilled during suctioning and (2) to describe the rates of occlusion of endotracheal tubes and nosocomial pneumonia.

METHODS

A convenience sample of 24 critically ill patients were enrolled before having suctioning and after informed consent had been given. Ages ranged from 10 weeks to 14 years. Patients were randomized to 1 of 2 groups. In group 1, subjects received between 0.5 and 2.0 mL of isotonic sodium chloride solution, depending on their age, once per suctioning episode. In group 2, subjects received no such solution. A total of 104 suctioning episodes were analyzed. Oxygen saturation was recorded at predetermined intervals before and for 10 minutes after suctioning. Occlusion of endotracheal tubes and rates of nosocomial pneumonia also were compared.

RESULTS

Patients who had isotonic sodium chloride solution instilled experienced significantly greater oxygen desaturation 1 and 2 minutes after suctioning than did patients who did not. No occlusions of endotracheal tubes and no cases of nosocomial pneumonia occurred in either group.

CONCLUSIONS

Results of this study support a growing body of evidence that instillation of isotonic sodium chloride solution during endotracheal tube suctioning may not be beneficial and actually may be harmful.

摘要

背景

气管内插管吸痰时滴注等渗氯化钠溶液存在争议。研究主要集中在其对成人的影响;尚无关于儿童的研究发表。

目的

(1)描述吸痰时滴注与不滴注等渗氯化钠溶液时氧饱和度的差异,(2)描述气管内插管堵塞率和医院获得性肺炎发生率。

方法

选取24例危重症患者作为便利样本,在吸痰前并获得知情同意后纳入研究。年龄范围为10周龄至14岁。患者被随机分为2组。第1组患者根据年龄在每次吸痰时接受0.5至2.0 mL等渗氯化钠溶液。第2组患者不接受该溶液。共分析104次吸痰过程。在吸痰前及吸痰后10分钟按预定时间间隔记录氧饱和度。同时比较气管内插管堵塞情况和医院获得性肺炎发生率。

结果

滴注等渗氯化钠溶液的患者在吸痰后1分钟和2分钟时氧饱和度下降明显大于未滴注的患者。两组均未发生气管内插管堵塞及医院获得性肺炎病例。

结论

本研究结果支持越来越多的证据表明,气管内插管吸痰时滴注等渗氯化钠溶液可能并无益处,实际上可能有害。

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