Schimpff S C, Brager D M, Schimpff C R, Comstock G W, Wiernik P H
Ann Intern Med. 1976 May;84(5):547-50. doi: 10.7326/0003-4819-84-5-547.
A case-control approach was used to evaluate whether patients with leukemia or lymphoma have a greater than expected tendency to have had prior close personal associations. Two census enumeration districts in different states with low population mobility were chosen, and each resident who had developed leukemia or lymphoma during a predetermined fixed interval was ascertained by review of tumor registry records. For each patient, a resident of the area was selected as a control matched for age, sex, race, and geographic location as of the time of diagnosis. Close personal associations between patients, controls, and both were determined by interviewing. In Area 1 the 8 patients had 11 social links (3 direct, 8 indirect) and the controls had 2 (both direct); P=0.0156, one-tailed significance test. In Area 2, the 21 patients had 21 close links (15 direct, 6 indirect) whereas the controls had 10 (direct 8, indirect 2; 0.25 greater than P greater than 0.20).
采用病例对照研究方法，评估白血病或淋巴瘤患者此前存在密切个人关联的倾向是否高于预期。选择了不同州人口流动性较低的两个普查枚举区，通过查阅肿瘤登记记录确定在预定固定时间段内患白血病或淋巴瘤的每位居民。为每位患者挑选一名该地区居民作为对照，对照在诊断时的年龄、性别、种族和地理位置与患者相匹配。通过访谈确定患者、对照以及两者之间的密切个人关联。在地区1，8例患者有11个社会联系（3个直接联系，8个间接联系），对照有2个（均为直接联系）；P = 0.0156，单尾显著性检验。在地区2，21例患者有21个密切联系（15个直接联系，6个间接联系），而对照有10个（直接联系8个，间接联系2个；0.25＞P＞0.20）。
