Kunugi Hiroshi, Urushibara Takako, Murray Robin M, Nanko Shinichiro, Hirose Tetsuya
Department of Psychiatry, Teikyo University School of Medicine, Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Psychiatry Clin Neurosci. 2003 Jun;57(3):271-4. doi: 10.1046/j.1440-1819.2003.01116.x.
A case is described herein of monozygotic twins discordant for schizophrenia that illustrates possible causal events of prenatal underdevelopment, morphological changes in the brain, poor premorbid functioning, and the development of schizophrenia. The affected twin was born with a birthweight of 1620 g, whereas the unaffected twin weighed 2300 g at birth. Marked differences in sociability and intelligence were observed between the twins from early childhood. Magnetic resonance imaging of the brain revealed high-intensity signals in the white matter and enlarged ventricles in the affected twin, while no such abnormality was detected in the well twin. This twin pair suggests a possibility that hypoxic brain damage associated with prenatal underdevelopment may be a causal factor for abnormalities in psychosocial development and subsequent schizophrenia.
本文描述了一对患精神分裂症的单卵双胞胎的病例，该病例说明了产前发育不全、大脑形态变化、病前功能不佳以及精神分裂症发展的可能因果事件。患病双胞胎出生时体重为1620克，而未患病的双胞胎出生时体重为2300克。从幼儿期起，就观察到这对双胞胎在社交能力和智力方面存在明显差异。对大脑进行的磁共振成像显示，患病双胞胎的白质中有高强度信号，脑室扩大，而健康双胞胎未检测到此类异常。这对双胞胎表明，与产前发育不全相关的缺氧性脑损伤可能是心理社会发育异常及随后患精神分裂症的一个因果因素。
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