Suppr超能文献

一项针对同卵双胞胎中患精神分裂症一致和不一致情况的大脑结构对照研究。

A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia.

作者信息

van Haren Neeltje E M, Picchioni Marco M, McDonald Colm, Marshall Nicolette, Davis Nadia, Ribchester Tracey, Hulshoff Pol Hilleke E, Sharma Tonmoy, Sham Pak, Kahn René S, Murray Robin

机构信息

Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.

出版信息

Biol Psychiatry. 2004 Sep 15;56(6):454-61. doi: 10.1016/j.biopsych.2004.06.033.

Abstract

BACKGROUND

We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities.

METHODS

Magnetic resonance imaging brain scans were obtained from 14 monozygotic twin pairs concordant and 10 monozygotic pairs discordant for schizophrenia, as well as 17 pairs of monozygotic control twins. Twenty-two discordant sibling-pairs and 56 pairs of unrelated control subjects were included to assess the extent of genetic control over these structures.

RESULTS

Within-pair similarities for whole brain volume increased as pair members were more closely related genetically (monozygotic twins > siblings > unrelated control subjects). Schizophrenic twins, whether from concordant or discordant pairs, had smaller whole brain volumes than control twins. The probands of discordant pairs showed more abnormalities in hippocampal, third and lateral ventricular volumes than concordant twins.

CONCLUSIONS

Whole brain volume is under high genetic control and smaller whole brain volume is a reflection of the genetic liability to develop schizophrenia. The variation in hippocampal and ventricular volumes within discordant monozygotic pairs indicates a role for environmental factors in determining these volume abnormalities in schizophrenia. Such factors may also underlie the more extensive morphometric deviations in patients from monozygotic discordant twins than in their counterparts from concordant twins.

摘要

背景

我们研究了患精神分裂症的同卵双胞胎和未患精神分裂症的同卵双胞胎,以阐明遗传和环境因素在决定脑部异常中的作用。

方法

对14对患精神分裂症的同卵双胞胎、10对患精神分裂症的同卵双胞胎中的一方以及17对同卵对照双胞胎进行了脑部磁共振成像扫描。纳入了22对不一致的同胞对和56对无关对照受试者,以评估这些结构的遗传控制程度。

结果

随着双胞胎成员之间的遗传关系更密切(同卵双胞胎>同胞>无关对照受试者),全脑体积的双胞胎内相似性增加。患精神分裂症的双胞胎,无论是来自一致对还是不一致对,其全脑体积均小于对照双胞胎。不一致对中的先证者在海马体、第三脑室和侧脑室体积方面比一致双胞胎表现出更多异常。

结论

全脑体积受高度遗传控制,较小的全脑体积反映了患精神分裂症的遗传易感性。不一致的同卵双胞胎对中海马体和脑室体积的差异表明环境因素在决定精神分裂症患者这些体积异常中起作用。这些因素也可能是导致单卵不一致双胞胎患者比单卵一致双胞胎患者出现更广泛形态学偏差的原因。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验