CD4(+)CD3(-)辅助细胞在T细胞与B细胞协作的位点，通过OX40和CD30共刺激已致敏的CD4 T细胞。

CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.

作者信息

Kim Mi-Yeon, Gaspal Fabrina M C, Wiggett Helen E, McConnell Fiona M, Gulbranson-Judge Adam, Raykundalia Chandra, Walker Lucy S K, Goodall Margaret D, Lane Peter J L

机构信息

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, United Kingdom.

出版信息

Immunity. 2003 May;18(5):643-54. doi: 10.1016/s1074-7613(03)00110-9.

DOI:10.1016/s1074-7613(03)00110-9

PMID:12753741

Abstract

In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen. Unlike dendritic cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-primed cells express the receptors for these TNF ligands and preferentially survive when cocultured with these cells. Furthermore, we show that the preferential survival of OX40(+) T cells and support of memory T cell help for B cells are linked to their association with CD4(+)CD3(-) cells in vivo.

摘要

在本报告中，我们鉴定出一种辅助细胞，它在与B细胞协作的位点与致敏T细胞和记忆T细胞相互作用。这些细胞与传统树突状细胞不同，它们对Flt3配体无反应且无法处理抗原。与树突状细胞不同，CD4(+)CD3(-)细胞几乎不表达CD80或CD86，但确实高水平表达TNF配体、OX40配体和CD30配体。我们发现，Th2致敏细胞表达这些TNF配体的受体，并且在与这些细胞共培养时优先存活。此外，我们表明，OX40(+) T细胞的优先存活以及记忆T细胞对B细胞辅助作用的支持与它们在体内与CD4(+)CD3(-)细胞的关联有关。