Kanis J A, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby A K
WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK.
Bone. 2003 May;32(5):468-73. doi: 10.1016/s8756-3282(03)00061-9.
A high excess mortality is well described after hip fracture. Deaths are in part related to comorbidity and in part due directly or indirectly to the hip fracture event itself (causally related deaths). The aim of this study was to examine the quantum and pattern of mortality following hip fracture. We studied 160,000 hip fractures in men and women aged 50 years or more, in 28.8 million person-years from the patient register of Sweden, using Poisson models applied to hip fracture patients and the general population. At all ages the risk of death was markedly increased compared with population values immediately after the event. Mortality subsequently decreased over a period of 6 months, but thereafter remained higher than that of the general population. The latter function was assumed to account for deaths related to comorbidity and the residuum assumed to be due to the hip fracture. Causally related deaths comprised 17-32% of all deaths associated with hip fracture (depending on age) and accounted for more than 1.5% of all deaths in the population aged 50 years or more. Hip fracture was a more common cause for mortality than pancreatic or stomach cancer. Thus, interventions that decreased hip fracture rate by, say, 50% would avoid 0.75% or more of all deaths.
髋部骨折后高超额死亡率已得到充分描述。死亡部分与合并症有关,部分直接或间接归因于髋部骨折事件本身(因果相关死亡)。本研究的目的是检查髋部骨折后的死亡数量和模式。我们利用应用于髋部骨折患者和一般人群的泊松模型,对瑞典患者登记处2880万人年中50岁及以上男性和女性的160000例髋部骨折进行了研究。在所有年龄段,事件发生后立即与人群值相比死亡风险显著增加。死亡率随后在6个月内下降,但此后仍高于一般人群。假定后者的作用是合并症相关死亡,剩余部分假定归因于髋部骨折。因果相关死亡占髋部骨折相关所有死亡的17%-32%(取决于年龄),占50岁及以上人群所有死亡的1.5%以上。髋部骨折是比胰腺癌或胃癌更常见的死亡原因。因此,例如将髋部骨折率降低50%的干预措施将避免所有死亡的0.75%或更多。