Malec Edward, Januszewska Katarzyna, Kolcz Jacek, Mroczek Tomasz
Department of Paediatric Cardiac Surgery, Collegium Medicum, Jagiellonian University, Cracow, Poland.
Eur J Cardiothorac Surg. 2003 May;23(5):728-33; discussion 733-4. doi: 10.1016/s1010-7940(03)00072-1.
The aim of this study was to assess changes in early and late haemodynamic status after the Norwood procedure (NP), caused by the implementation of right ventricle-to-pulmonary artery shunt (RV-PA).
A consecutive series of 68 children with hypoplastic left heart syndrome underwent NP: Group 1 (n=31) with the application of a modified Blalock-Taussig shunt and Group 2 (n=37) with RV-PA. Haemodynamic data from the early postoperative period (72 h after the operation) and cardiac catheterisation data, as well as blood tests before the hemi-Fontan procedure (HF) were analysed. Univariate (chi(2) test, Mann-Whitney's and Student's t-tests) and multiple regression analysis were carried out.
In Group 1, circulatory collapse requiring resuscitation occurred in 15 (48.4%) children, within 72 h after the procedure. The resuscitation was unsuccessful in nine (29%) cases. The operative mortality (30 days) was 35%. In Group 2, two (5%) children died within the early and two (5%) within the late postoperative period. The postoperative course in the remaining children from Group 2 was uneventful. In Group 2 there was a significantly higher mean diastolic pressure after NP (P<0.05). The arterial pulse pressure after NP was significantly lower in Group 2 (P<0.05). Before HF, the application of RV-PA was associated with a lower Qp:Qs ratio (P=0.020), lower aortic pulse pressure (P=0.004) and lower aortic oxygen saturation (P=0.039).
A stable haemodynamic status due to independent coronary perfusion, higher diastolic and lower pulse pressure is the most advantageous effect of RV-PA, resulting in a lower mortality and morbidity after NP. A lower Qp:Qs ratio eliminates the danger of the ventricular volume overload and ensures good conditions for the development of the pulmonary circulation before HF.
本研究旨在评估实施右心室至肺动脉分流术(RV-PA)后诺伍德手术(NP)早期和晚期血流动力学状态的变化。
连续纳入68例左心发育不全综合征患儿接受NP:第1组(n = 31)应用改良布莱洛克-陶西格分流术,第2组(n = 37)应用RV-PA。分析术后早期(术后72小时)的血流动力学数据、心导管检查数据以及半Fontan手术(HF)前的血液检查结果。进行单因素分析(卡方检验、曼-惠特尼检验和学生t检验)和多元回归分析。
第1组中,15例(48.4%)患儿在术后72小时内发生需要复苏的循环衰竭。9例(29%)复苏失败。手术死亡率(30天)为35%。第2组中,2例(5%)患儿在术后早期死亡,2例(5%)在术后晚期死亡。第2组其余患儿术后病程平稳。第2组NP术后平均舒张压显著更高(P<0.05)。第2组NP术后动脉脉压显著更低(P<0.05)。在HF前,应用RV-PA与更低的Qp:Qs比值(P = 0.020)、更低的主动脉脉压(P = 0.004)和更低的主动脉血氧饱和度(P = 0.039)相关。
由于独立的冠状动脉灌注导致血流动力学状态稳定、舒张压更高和脉压更低是RV-PA最有利的效果,这导致NP术后死亡率和发病率更低。更低的Qp:Qs比值消除了心室容量超负荷的危险,并确保了HF前肺循环发育的良好条件。