长期随访研究证实了静息CD4 + T细胞中HIV-1潜伏库的稳定性。

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

作者信息

Siliciano Janet D, Kajdas Joleen, Finzi Diana, Quinn Thomas C, Chadwick Karen, Margolick Joseph B, Kovacs Colin, Gange Stephen J, Siliciano Robert F

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.

出版信息

Nat Med. 2003 Jun;9(6):727-8. doi: 10.1038/nm880. Epub 2003 May 18.

DOI:10.1038/nm880

PMID:12754504

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.

摘要

潜伏的HIV-1存在于静止的记忆CD4+ T细胞中，即使在接受高效抗逆转录病毒疗法（HAART）的患者中也是如此。目前尚不清楚这个潜伏库有多稳定，以及其持续存在是否反映了低水平病毒血症的补充。我们在此表明，即使在长达7年未检测到病毒血症的接受治疗的患者中，这个病毒库的衰减也非常缓慢（半衰期 = 44个月），以至于根除几乎是不可能的。