Haro J M, Kamath S A, Ochoa S, Novick D, Rele K, Fargas A, Rodríguez M J, Rele R, Orta J, Kharbeng A, Araya S, Gervin M, Alonso J, Mavreas V, Lavrentzou E, Liontos N, Gregor K, Jones P B
Research and Development Unit, Sant Joan de Déu-SSM, Sant Boi, Barcelona, Spain.
Acta Psychiatr Scand Suppl. 2003(416):16-23. doi: 10.1034/j.1600-0447.107.s416.5.x.
To describe the development and validation of the Clinical Global Impression-Schizophrenia (CGI-SCH) scale, designed to assess positive, negative, depressive and cognitive symptoms in schizophrenia.
The CGI-SCH scale was adapted from the CGI scale. Concurrent validity and sensitivity to change were assessed by comparison with the Positive and Negative Symptom Severity (PANSS) and Global Assessment of Functioning (GAF) scales. To evaluate inter-rater reliability, all patients were assessed by two clinicians.
Symptoms were assessed in 114 patients. Correlation coefficients between the CGI-SCH and the GAF and PANSS scores were high (most above 0.75), and were highest for positive and negative symptoms. Reliability was substantial (intraclass correlation coefficient, ICC > 0.70) in all but one dimension (depressive dimension, ICC = 0.64).
The CGI-SCH scale is a valid, reliable instrument to evaluate severity and treatment response in schizophrenia. Given its simplicity, brevity and clinical face validity, the scale is appropriate for use in observational studies and routine clinical practice.
描述临床总体印象-精神分裂症（CGI-SCH）量表的开发与验证情况，该量表旨在评估精神分裂症的阳性、阴性、抑郁和认知症状。
CGI-SCH量表改编自CGI量表。通过与阳性和阴性症状量表（PANSS）及功能总体评定量表（GAF）比较，评估其同时效度和变化敏感性。为评估评定者间信度，由两名临床医生对所有患者进行评估。
对114例患者的症状进行了评估。CGI-SCH与GAF及PANSS评分之间的相关系数较高（大多高于0.75），其中阳性和阴性症状的相关系数最高。除一个维度（抑郁维度，组内相关系数ICC = 0.64）外，所有维度的信度均较高（组内相关系数ICC > 0.70）。
CGI-SCH量表是评估精神分裂症严重程度和治疗反应的有效、可靠工具。鉴于其简单、简短且具有临床表面效度，该量表适用于观察性研究和常规临床实践。
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