Delgado M C, Delgado-Almeida A
Division of Hypertension, University of Michigan, Ann Arbor, MI 481091, USA.
J Hum Hypertens. 2003 May;17(5):313-8. doi: 10.1038/sj.jhh.1001527.
The aim of this study is to determine whether red blood cell K(+) content (RBC(Ki)) is associated with blood pressure levels and, if so, could RBC(Ki) be a marker of potassium changes in other cells involved in blood pressure regulation. The study was performed on 50 untreated hypertensives, 32 of their offspring and 50 age- and sex-matched controls. Systolic (SBP) and diastolic (DBP) blood pressures, height, weight, plasma, urine and red blood cell electrolytes were measured in all subjects. RBC(Ki) was significantly lower in hypertensives than in offspring of hypertensives and normotensive controls. Offspring of hypertensives had significantly lower RBC(Ki) than normotensive controls. Plasma K(+) was significantly lower both in hypertensives and offspring of hypertensives when compared to normotensive controls. A significant negative correlation was found in hypertensives between RBC(Ki) and DBP (r=-0.27, P=0.04) and in offspring of hypertensives between RBC(Ki) and DBP (r=-0.43, P=0.02). A significant correlation was found in hypertensives between RBC(Ki) and plasma K(+) (r=0.3, P=0.02). A positive correlation with borderline significance was found in hypertensives between RBC(Ki) and ionized Ca(2+) (r=0.2, P=0.1). In conclusion, our results support the hypothesis that RBC(Ki) is associated with blood pressure levels and that the measurement of RBC(Ki) levels may represent a biochemical marker for K(+) changes in other cells involved in blood pressure regulation. Further studies are necessary to explain the exact mechanisms of reduced RBC(Ki) levels in hypertensive patients and their offspring.
本研究的目的是确定红细胞钾含量（RBC(Ki)）是否与血压水平相关，若相关，RBC(Ki)能否作为参与血压调节的其他细胞中钾变化的标志物。该研究对50例未经治疗的高血压患者、其中32例患者的后代以及50例年龄和性别匹配的对照者进行。测量了所有受试者的收缩压（SBP）和舒张压（DBP）、身高、体重、血浆、尿液及红细胞电解质。高血压患者的RBC(Ki)显著低于高血压患者的后代和血压正常的对照者。高血压患者的后代RBC(Ki)显著低于血压正常的对照者。与血压正常的对照者相比，高血压患者及其后代的血浆钾均显著降低。在高血压患者中，RBC(Ki)与DBP之间存在显著负相关（r = -0.27，P = 0.04），在高血压患者的后代中，RBC(Ki)与DBP之间也存在显著负相关（r = -0.43，P = 0.02）。在高血压患者中，RBC(Ki)与血浆钾之间存在显著相关性（r = 0.3，P = 0.02）。在高血压患者中，RBC(Ki)与离子钙之间存在边缘显著的正相关（r = 0.2，P = 0.1）。总之，我们的结果支持以下假设：RBC(Ki)与血压水平相关，测量RBC(Ki)水平可能代表参与血压调节的其他细胞中钾变化的生化标志物。需要进一步研究来解释高血压患者及其后代RBC(Ki)水平降低的确切机制。
