Lotan R
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
J Biol Regul Homeost Agents. 2003 Jan-Mar;17(1):13-28.
Retinoids modulate cell proliferation, differentiation and apoptosis. Many of these effects are mediated by nuclear retinoid receptors. However, studies with certain synthetic retinoids, including some that can activate retinoid receptors, revealed that they affect cell growth and especially apoptosis by mechanisms that are independent of nuclear receptors. This chapter describes the pro-apoptotic effects of the synthetic retinoid CD437 [6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid], and structurally-related retinoids and summarizes the mechanisms by which they induce apoptosis.
维甲酸可调节细胞增殖、分化和凋亡。其中许多效应是由核维甲酸受体介导的。然而，对某些合成维甲酸（包括一些能激活维甲酸受体的化合物）的研究表明，它们通过独立于核受体的机制影响细胞生长，尤其是凋亡。本章描述了合成维甲酸CD437 [6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸]以及结构相关维甲酸的促凋亡作用，并总结了它们诱导凋亡的机制。
