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[作为将异种硬脑膜用于血管整形手术依据的实验形态学研究结果]

[Experimental morphologic findings serving as a basis for use of xenogenic dura mater for plastic surgery of blood vessels].

作者信息

Ziablov V I, Toskin K D, Tkach V V, Shapovalov Iu N, Zhebrovskiĭ V V

出版信息

Arkh Anat Gistol Embriol. 1976 Apr;70(4):66-72.

PMID:1275730
Abstract

Heterotransplants of the human dura mater were used to replace circular and lateral defects of the thoracic and abdominal aortas, carotid and iliac arteries in experiment. Operations were performed in 106 dogs. Observations of permeability of the vessels, morphological and histochemical studies were carried out at different periods after operation (from 1 day to 2 years). The xenogenous dura mater has well pronounced plastic properties--it is solid, elastic, characterized by low antigenicity. During transplantation there appear no hard inflammatory--destructive changes in reconstructed vessels and the surrounding tissues. The transplant is gradually substituted by recipients tissues characterized by high specialization. They are rich in elastic and smooth muscle fibres, have good blood supply and innervation. The dura mater is a good material for plastics of vascular wall defects.

摘要

在实验中,使用人硬脑膜异种移植物来替代胸主动脉、腹主动脉、颈动脉和髂动脉的环形及侧方缺损。对106只狗进行了手术。在术后不同时期(从1天到2年)对血管通透性进行了观察,并开展了形态学和组织化学研究。异种硬脑膜具有明显良好的可塑性——质地坚实、有弹性,抗原性低。移植过程中,重建血管及周围组织未出现严重的炎症性破坏改变。移植物逐渐被高度特化的受体组织所替代。这些组织富含弹性纤维和平滑肌纤维,血液供应和神经支配良好。硬脑膜是修复血管壁缺损的良好材料。

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