攻击紫外线照射过的DNA的粗糙脉孢菌的酶。

Enzymes of Neurospora crassa which attack UV-irradiated DNA.

作者信息

Fraser M J

出版信息

Basic Life Sci. 1975;5B:577-9. doi: 10.1007/978-1-4684-2898-8_23.

DOI:10.1007/978-1-4684-2898-8_23

Abstract

Two excision-deficient mutants of Neurospora crassa contain normal levels of two enzymes, a single-strand-specific exonuclease and a single-strand specific endonuclease, which attack UV-irradiated DNA. Mutants of N. crassa have been obtained in which the activity of the latter enzyme as well as an activity with native DNA are simultaneously affected. These activities are also apparently low in excision-proficient uvs3 strain of N. crassa which has many of the characteristics of the recA mutants of E. coli.

摘要

粗糙脉孢菌的两个切除缺陷型突变体含有两种酶的正常水平，一种单链特异性核酸外切酶和一种单链特异性核酸内切酶，它们攻击紫外线照射的DNA。已经获得了粗糙脉孢菌的突变体，其中后一种酶的活性以及与天然DNA的活性同时受到影响。在具有许多大肠杆菌recA突变体特征的粗糙脉孢菌切除 proficient uvs3 菌株中，这些活性显然也很低。

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