• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure.前手性中心的手性识别和一般酸碱催化。活性位点结构必然相互关联的表现形式。
Biochem J. 1976 Feb 1;153(2):491-3. doi: 10.1042/bj1530491.
2
The use of ternary complexes to study ionizations and isomerizations during catalysis by lactate dehydrogenase.利用三元复合物研究乳酸脱氢酶催化过程中的电离和异构化。
Biochem J. 1973 Apr;131(4):739-48. doi: 10.1042/bj1310739.
3
Glyoxylate oxidation in rat liver and kidney.大鼠肝脏和肾脏中的乙醛酸氧化作用。
J Biochem. 1977 Jul;82(1):221-30. doi: 10.1093/oxfordjournals.jbchem.a131673.
4
Stereochemistry of glyoxylate oxidation by NAD and mammalian lactate dehydrogenase.
Biochim Biophys Acta. 1970 Sep 16;212(3):503-5. doi: 10.1016/0005-2744(70)90257-3.
5
Oxalate and glycolate synthesis by hemic cells.血细胞合成草酸盐和乙醇酸盐。
J Lab Clin Med. 1971 Aug;78(2):245-54.
6
D-lactate dehydrogenase binding in Escherichia coli dld- membrane vesicles reconstituted for active transport.在为主动运输而重构的大肠杆菌dld -膜囊泡中D -乳酸脱氢酶的结合
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1461-5. doi: 10.1073/pnas.71.4.1461.
7
Occurrence and operation of the glycollate--glyoxylate shuttle in mitochondria of Euglena gracilis Z.纤细裸藻Z线粒体中乙醇酸-乙醛酸穿梭的发生与运作
Biochem J. 1979 Oct 15;184(1):189-92. doi: 10.1042/bj1840189.
8
Glyoxylate as a substrate for lactate dehydrogenase.乙醛酸作为乳酸脱氢酶的底物。
Nature. 1967 Feb 18;213(5077):726-7. doi: 10.1038/213726a0.
9
The disproportionation of glyoxylate by lactate dehydrogenase.
Arch Biochem Biophys. 1980 Apr 15;201(1):128-36. doi: 10.1016/0003-9861(80)90496-8.
10
The localization of glycollate-pathway enzymes in Euglena.乙醇酸途径酶在眼虫中的定位。
Biochem J. 1975 May;148(2):321-8. doi: 10.1042/bj1480321.

本文引用的文献

1
DETERMINATION BY NEUTRON AND X-RAY DIFFRACTION OF THE ABSOLUTE CONFIGURATION OF AN ENZYMATICALLY FORMED ALPHA-MONO DEUTERIOGLYCOLATE.
J Am Chem Soc. 1965 Apr 20;87:1802-4. doi: 10.1021/ja01086a039.
2
Preparation and detection of chiral methyl groups.手性甲基的制备与检测
Nature. 1969 Mar 29;221(5187):1213-5. doi: 10.1038/2211213a0.
3
Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule.
Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):437-64.
4
Macroscopic rate constants involved in the formation and interconversion of the two central enzyme--substrate complexes of the lactate dehydrogenase turnover.参与乳酸脱氢酶周转的两个核心酶 - 底物复合物形成和相互转化的宏观速率常数。
Biochem J. 1974 Apr;139(1):261-71. doi: 10.1042/bj1390261.
5
The lactate dehydrogenase--reduced nicotinamide--adenine dinucleotide--pyruvate complex. Kinetics of pyruvate binding and quenching of coeznyme fluorescence.乳酸脱氢酶-还原型烟酰胺-腺嘌呤二核苷酸-丙酮酸复合物。丙酮酸结合动力学及辅酶荧光猝灭。
Biochem J. 1974 Apr;139(1):251-9. doi: 10.1042/bj1390251.
6
Facilitated proton transfer in enzyme catalysis. It may have a crucial role in determining the efficiency and specificity of enzymes.酶催化中的质子传递促进作用。它可能在决定酶的效率和特异性方面发挥关键作用。
Science. 1968 Jul 26;161(3839):328-34. doi: 10.1126/science.161.3839.328.
7
Structure-function relationships in lactate dehydrogenase.乳酸脱氢酶的结构-功能关系
Proc Natl Acad Sci U S A. 1973 Jul;70(7):1968-72. doi: 10.1073/pnas.70.7.1968.
8
Roles of zinc ion and reduced coenzyme in horse liver alcohol dehydrogenase catalysis. The mechanism of aldehyde activation.
Biochemistry. 1975 Jul 15;14(14):3176-82. doi: 10.1021/bi00685a022.

前手性中心的手性识别和一般酸碱催化。活性位点结构必然相互关联的表现形式。

Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure.

作者信息

Südi J

出版信息

Biochem J. 1976 Feb 1;153(2):491-3. doi: 10.1042/bj1530491.

DOI:10.1042/bj1530491
PMID:1275899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172598/
Abstract

On the basis of Ogston's [(1948) Nature (London) 162, 963] argument, the following conclusions are indicated by the stereochemistry of the reversible oxidation of glycollate by lactate dehydrogenase: (1) general acid-base catalysis is involved in the reaction; (2) the transformation of enzyme-bound (tetrahedral) substrate into enzyme-bound (trigonal) product involves a conformational transition of the enzyme-coenzyme complex.

摘要

基于奥格斯顿[（1948年）《自然》（伦敦）162, 963]的观点，乙醇酸被乳酸脱氢酶可逆氧化反应的立体化学表明了以下结论：（1）该反应涉及一般酸碱催化；（2）酶结合的（四面体）底物向酶结合的（三角）产物的转变涉及酶-辅酶复合物的构象转变。