前手性中心的手性识别和一般酸碱催化。活性位点结构必然相互关联的表现形式。
Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure.
作者信息
Südi J
出版信息
Biochem J. 1976 Feb 1;153(2):491-3. doi: 10.1042/bj1530491.
Abstract
On the basis of Ogston's [(1948) Nature (London) 162, 963] argument, the following conclusions are indicated by the stereochemistry of the reversible oxidation of glycollate by lactate dehydrogenase: (1) general acid-base catalysis is involved in the reaction; (2) the transformation of enzyme-bound (tetrahedral) substrate into enzyme-bound (trigonal) product involves a conformational transition of the enzyme-coenzyme complex.
摘要
基于奥格斯顿[（1948年）《自然》（伦敦）162, 963]的观点，乙醇酸被乳酸脱氢酶可逆氧化反应的立体化学表明了以下结论：（1）该反应涉及一般酸碱催化；（2）酶结合的（四面体）底物向酶结合的（三角）产物的转变涉及酶-辅酶复合物的构象转变。
相似文献
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Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure.前手性中心的手性识别和一般酸碱催化。活性位点结构必然相互关联的表现形式。
Biochem J. 1976 Feb 1;153(2):491-3. doi: 10.1042/bj1530491.
2
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