Koga Tsuyoshi, Athayde Neil, Trudinger Brian
Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia.
J Soc Gynecol Investig. 2003 May;10(4):194-9. doi: 10.1016/s1071-5576(03)00043-1.
We developed a noninvasive Doppler technique for measuring fetal cardiac isovolumetric contraction time (ICT). The purpose of this study was to determine how well our method reflects real cardiac performance using fetal lamb as an instrumented model.
The true ICT was measured by simultaneous recording of the pressure waves of the left ventricle and ascending aorta. The maximum first derivative of the left ventricular pressure wave (Max dp/dt) was calculated. The Doppler ICT was measured in the appropriately filtered Doppler cardiac signals. Positive and negative inotropic agents were administered to change the cardiac contractility.
There was an inverse relationship between the Doppler ICT and the Max dp/dt. Excellent linear correlation was found an absolute value and changes from control value between the true ICT and the Doppler ICT (r = 0.959, r = 0.962).
The Doppler ICT measurement provides useful information about changes in ventricular performance.
我们开发了一种用于测量胎儿心脏等容收缩时间（ICT）的无创多普勒技术。本研究的目的是使用仪器化的胎羊模型来确定我们的方法在多大程度上能够反映真实的心脏功能。
通过同时记录左心室和升主动脉的压力波来测量真实的ICT。计算左心室压力波的最大一阶导数（Max dp/dt）。在经过适当滤波的多普勒心脏信号中测量多普勒ICT。给予正性和负性肌力药物以改变心脏收缩力。
多普勒ICT与Max dp/dt之间呈负相关。在真实ICT与多普勒ICT的绝对值以及与对照值的变化之间发现了极好的线性相关性（r = 0.959，r = 0.962）。
多普勒ICT测量为心室功能的变化提供了有用信息。
