Szulczyk Bartłomiej, Szulczyk Paweł
Department of Experimental and Clinical Physiology, Medical University of Warsaw, Faculty of Medicine, Krakowskie Przedmiescie 26/28, Warsaw 00-927, Poland.
Neurosci Lett. 2003 Jun 5;343(2):105-8. doi: 10.1016/s0304-3940(03)00352-5.
The kinetic properties of voltage-gated Na(+) currents in two groups of glandular postganglionic sympathetic neurons were assessed. The first group of neurons remained innervated by preganglionic axons until the day of current recordings, while the second--decentralized 4 weeks prior to recordings. An increase of maximum current amplitude and density was noted in decentralized neurons. Na(+) currents activated and time-dependently inactivated more slowly in decentralized than in control neurons. Furthermore, after decentralization the currents steady-state inactivated at less hyperpolarized potentials as well as reactivated faster from inactivation. We conclude that the Na(+) currents in decentralized postganglionic glandular sympathetic neurons undergo up-regulation.
评估了两组节后腺性交感神经元中电压门控性钠电流的动力学特性。第一组神经元在进行电流记录当天仍受节前轴突支配，而第二组在记录前4周已去传入。去传入神经元的最大电流幅度和密度增加。与对照神经元相比，去传入神经元中钠电流的激活和时间依赖性失活更慢。此外，去传入后，电流在较不超极化的电位下达到稳态失活，并且从失活状态重新激活更快。我们得出结论，去传入节后腺性交感神经元中的钠电流发生了上调。
