15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells.

作者信息

Imaizumi Tadaatsu, Kumagai Mika, Nishi Nozomu, Hirashima Mitsuomi, Hatakeyama Masaharu, Tamo Wakako, Yoshida Hidemi, Nakamura Takanori, Okumura Ken, Satoh Kei

机构信息

Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki, Japan.

出版信息

Int Arch Allergy Immunol. 2003 May;131(1):57-61. doi: 10.1159/000070436.

BACKGROUND

Galectin-9 is involved in chemotaxis and adhesion of eosinophils, and is induced in vascular endothelial cells by interferon-gamma (IFN-gamma). 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and known to modulate the expression of various genes.

METHODS

We have studied the effect of 15d-PGJ(2) on the IFN-gamma-induced galectin-9 expression in human umbilical vein endothelial cells (HUVEC) in culture.

RESULTS

15d-PGJ(2) inhibited the IFN-gamma-induced galectin-9 expression in a PPAR-gamma-independent manner, and also inhibited the adhesion of EoL-1 cells to an HUVEC monolayer treated with IFN-gamma. 15d-PGJ(2) partially inhibited IFN-gamma-induced phosphorylation of STAT-1 in HUVEC.

CONCLUSIONS

15d-PGJ(2) may regulate inflammatory reactions through the inhibition of galectin-9 expression.