[2000 - 2001年103株肺炎链球菌临床分离株对青霉素及其他抗菌药物的耐药性]

[Resistance to penicillin and other antimicrobials in 103 clinical isolations of Streptococcus pneumoniae (2000-2001)].

作者信息

García-Irure J J, Navascués A, Martín I, Gastesi C

机构信息

Servicio de Microbiología, Hospital de Navarra, Irunlarrea 3, 31008 Pamplona, Spain.

出版信息

An Sist Sanit Navar. 2003 Jan-Apr;26(1):27-33. doi: 10.23938/ASSN.0460.

DOI:10.23938/ASSN.0460

PMID:12759709

Abstract

BACKGROUND

To determine in our hospital the sensitivity of isolations of Streptococcus pneumoniae to penicillin, as well as to analyse the association of resistance to penicillin and other antimicrobials and the activity of cefotaxime and cefepime in pencillin resistant strains of Streptococcus pneumoniae.

METHODS

The sensitivity was determined on 103 isolations of Streptococcus pneumoniae, from clinical samples from the years 2000-2001, to penicillin, eritromycine, cloramfenicol, tetracycline, cotrimoxazol, cefotaxime, cefepime and levofloxacine.

RESULTS

Sixty-eight percent of the isolations were sensitive to penicillin, while some 32% of the isolated strains of Streptococcus pneumoniae were penicillin resistant, with 7.7% showing a high degree of resistance. Resistance to eritromycine, cloramfenicol, tetracycline, cotrimoxazol and levofloxacine was 38.8%; 9.7%; 20.4%; 25.2% and 2.9% respectively, increasing to values of 66.6%; 30.3%; 48.5%; 72.7% and 9.1% in the 33 penicillin resistant strains. Resistance to cefotaxime and cefepime was 9.7% and 10.6% respectively. CONCLUSIONS. A high percentage of strains of Streptococcus pneumoniae show some degree of resistance to penicillin, but with lower figures than in other studies carried out at a national level. Similarly, it was demonstrated that resistance to penicillin is significantly associated (p < 0.001) with resistance to all the antimicrobials studied, except for levofloxacine. The resistances to cefotaxime and cefepime were comparable, with less activity being observed in these when facing penicillin resistant strains of Streptococcus pneumoniae.

摘要

背景

为确定我院肺炎链球菌分离株对青霉素的敏感性，以及分析肺炎链球菌青霉素耐药性与其他抗菌药物耐药性的相关性，和头孢噻肟及头孢吡肟对青霉素耐药肺炎链球菌菌株的活性。

方法

对2000 - 2001年临床样本中分离出的103株肺炎链球菌进行了对青霉素、红霉素、氯霉素、四环素、复方新诺明、头孢噻肟、头孢吡肟和左氧氟沙星的敏感性测定。

结果

68%的分离株对青霉素敏感，约32%的肺炎链球菌分离株对青霉素耐药，其中7.7%表现出高度耐药。对红霉素、氯霉素、四环素、复方新诺明和左氧氟沙星的耐药率分别为38.8%、9.7%、20.4%、25.2%和2.9%，在33株青霉素耐药菌株中分别增至66.6%、30.3%、48.5%、72.7%和9.1%。对头孢噻肟和头孢吡肟的耐药率分别为9.7%和10.6%。结论：相当比例的肺炎链球菌菌株对青霉素表现出一定程度的耐药性，但低于在国家层面开展的其他研究中的数据。同样，研究表明，除左氧氟沙星外，对青霉素的耐药性与对所有研究的抗菌药物的耐药性显著相关（p < 0.001）。对头孢噻肟和头孢吡肟的耐药情况相当，在面对青霉素耐药的肺炎链球菌菌株时，它们的活性较低。