López Uriarte A, Sánchez Burgos J, Santos Atherton D
Bol Med Hosp Infant Mex. 1976 May-Jun;33(3):693-8.
Nine infants without evidence of nephropathy were studied. After a control period, furosemide, 1.0 mg/kg. of body weight, was administered intravenously and urine was collected. In all patients, urinary volume increased from a mean of 0.15 ml/min. during the control period, to 0.69 ml/min. after furosemide and urinary sodium excretion rose from 1.77 micro Eq/min. in the first period, to 50.13 micro Eq/min. in the second. There was no significant change in urinary osmolarity and in serum electrolytes. Three hours after furosemide, all children showed dehydration from light to moderate and saline infusion was necessary. No correlation was found between age and weight of the infants with the response to furosemide. Because this diuretic has an energetic action in infants as in children and adults, it must be used carefully and it is proposed that the initial dose of furosemide in infants be 0.5 mg/kg.
对9名无肾病迹象的婴儿进行了研究。在一个对照期后，静脉注射速尿，剂量为1.0毫克/千克体重，然后收集尿液。在所有患者中，尿量从对照期的平均0.15毫升/分钟增加到速尿注射后的0.69毫升/分钟，尿钠排泄量从第一阶段的1.77微当量/分钟增加到第二阶段的50.13微当量/分钟。尿渗透压和血清电解质无显著变化。速尿注射三小时后，所有儿童均出现轻度至中度脱水，需要输注生理盐水。未发现婴儿的年龄和体重与对速尿的反应之间存在相关性。由于这种利尿剂在婴儿、儿童和成人中都有强效作用，必须谨慎使用，建议婴儿速尿的初始剂量为0.5毫克/千克。
