Issifou Saadou, Rogier Christophe, Adjagba-Olakpo Marius, Chabi-Worou Nicodème, Ntoumi Francine
Centre Régional pour le Développement et la Santé (CREDESA/SSP), Cotonou, Benin.
Parasitol Res. 2003 Aug;90(5):423-8. doi: 10.1007/s00436-003-0854-1. Epub 2003 May 21.
A site-based characterization of Plasmodium falciparum infections in children living in two malaria hyperendemic urban areas from West and Central Africa was undertaken. A total of 58 and 46 children with either asymptomatic infections or uncomplicated (symptomatic) malaria were recruited in Gabon and Benin, respectively. Parasite density, hematological factors, the genetic diversity of P. falciparum merozoite surface protein 2 (msp2) and the complexity of infections (mean number of P. falciparum genotypes per infected child) were used for this characterization. Gabonese children with uncomplicated malaria presented a higher mean axillary temperature (39.2 vs 38.6, P=0.004) and a higher geometric mean parasite density (30,538 vs 18,921, P<0.001) associated with a significantly lower hemoglobin level ( P<0.01). A higher degree of msp2 polymorphism and the complexity of P. falciparum infections were also observed in children from Gabon ( P<0.05). With a similar level of malaria transmission in both urban sites, these results suggest an impact of malaria control interventions on the dynamics of concurrent P. falciparum infections.
对生活在西非和中非两个疟疾高度流行城市地区的儿童中恶性疟原虫感染进行了基于地点的特征描述。在加蓬和贝宁分别招募了58名和46名患有无症状感染或单纯性（有症状）疟疾的儿童。寄生虫密度、血液学因素、恶性疟原虫裂殖子表面蛋白2（msp2）的遗传多样性以及感染的复杂性（每个感染儿童的恶性疟原虫基因型平均数）用于此特征描述。患有单纯性疟疾的加蓬儿童的平均腋窝温度较高（39.2对38.6，P = 0.004），几何平均寄生虫密度较高（30,538对18,921，P<0.001），且血红蛋白水平显著较低（P<0.01）。在加蓬儿童中还观察到更高程度的msp2多态性和恶性疟原虫感染的复杂性（P<0.05）。在两个城市地区疟疾传播水平相似的情况下，这些结果表明疟疾控制干预措施对同时发生的恶性疟原虫感染动态有影响。
