α干扰素增强了西多福韦的抗病毒和抗增殖活性。
Alpha interferon augments cidofovir's antiviral and antiproliferative activities.
作者信息
Johnson Jeffrey A, Gangemi J David
机构信息
Department of Microbiology and Molecular Medicine and the Greenville Hospital System Biomedical Cooperative, Clemson University, Clemson, South Carolina 29634, USA.
出版信息
Antimicrob Agents Chemother. 2003 Jun;47(6):2022-6. doi: 10.1128/AAC.47.6.2022-2026.2003.
Abstract
The antiviral and antiproliferative activities of alpha 2a interferon (IFN-alpha 2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-alpha 2a and cidofovir in inhibiting the proliferation of HPV-infected cells.
摘要
评估了α2a干扰素（IFN-α2a）和西多福韦在人乳头瘤病毒16型（HPV-16）转化的角质形成细胞中的抗病毒和抗增殖活性。联合使用这些化合物比单独使用任何一种药物达到同等水平时更有效。有效药物比例的评估显示，IFN-α2a和西多福韦在抑制HPV感染细胞增殖方面存在协同作用。
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