4-苯氧基苯氧乙基硫氰酸盐（WC-9）对恰加斯病病原体克氏锥虫的作用机制。
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.
作者信息
Urbina Julio A, Concepcion Juan Luis, Montalvetti Andrea, Rodriguez Juan B, Docampo Roberto
机构信息
Laboratorio de Quimica Biológica, Centro de Bioquimica y Biofisica, Instituto Venezolano de Investigaciones Cientificas, Carretera Panamericana, Caracas 1020, Venezuela.
出版信息
Antimicrob Agents Chemother. 2003 Jun;47(6):2047-50. doi: 10.1128/AAC.47.6.2047-2050.2003.
Abstract
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
摘要
我们研究了4-苯氧基苯氧基乙基硫氰酸盐（WC-9）对恰加斯病的病原体克氏锥虫的活性分子基础。我们发现，该化合物诱导的克氏锥虫前鞭毛体生长抑制与寄生虫内源性固醇含量的降低有关，这是由于在角鲨烯合酶水平上对其从头合成的特异性阻断。
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