Wüllner U, Klockgether T
Department of Neurology, University Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
J Neurol. 2003 Feb;250 Suppl 1:I35-8. doi: 10.1007/s00415-003-1107-x.
Several studies of Parkinson's disease (PD) patients and experimental models of PD indicate the presence of an inflammatory process in PD. Although the primary cellular mechanisms remain to be clarified, activation of resident microglia appears to aggravate or even maintain the disease process in PD. Modulation of inflammatory mechanisms could provide a new neuroprotective therapy in PD.
多项针对帕金森病（PD）患者及PD实验模型的研究表明，PD中存在炎症过程。尽管主要的细胞机制仍有待阐明，但常驻小胶质细胞的激活似乎会加剧甚至维持PD的疾病进程。调节炎症机制可为PD提供一种新的神经保护疗法。
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