Bahar Gideon, Feinmesser Raphael, Popovtzer Aharon, Ulanovsky David, Nageris Ben, Marshak Gideon, Feinmesser Meora
Department of Otolaryngology, Rabin Medical Center, Petah Tiqva, Israel.
Am J Otolaryngol. 2003 May-Jun;24(3):204-8. doi: 10.1016/s0196-0709(03)00004-8.
Basaloid squamous cell carcinoma (BSCC) is a distinct variant of squamous cell carcinoma that was first described by Wain et al in 1986. Since then, about 160 cases have been reported in the literature. Only 40 cases have been described in the larynx.
Four cases of BSCC of the larynx treated in our department between 1986 and 2000 are presented. The clinical features, biological behavior, and histopathological and immunohistochemical characteristics of this uncommon tumor are described, and the relevant literature is reviewed.
The main clinical presentation did not differ from other histological types of laryngeal carcinoma. The clinical course, however, was much more aggressive. All the patients received aggressive therapy including radical surgery and radiation. Two patients received chemotherapy. Two of the 4 patients presented died of distant metastasis shortly after diagnosis and treatment.
The finding of this study with a limited number of patients supports previous reports suggesting that BSCC is a highly aggressive tumor that presents in older population with male predominance. The frequency of associated regional as well as distant metastases suggests that aggressive treatment is indicated and that systemic chemotherapy should be contemplated.
基底样鳞状细胞癌（BSCC）是鳞状细胞癌的一种独特变体，于1986年由韦恩等人首次描述。自那时以来，文献中已报道了约160例病例。仅40例病例发生于喉部。
本文介绍了1986年至2000年间在我科接受治疗的4例喉部基底样鳞状细胞癌病例。描述了这种罕见肿瘤的临床特征、生物学行为以及组织病理学和免疫组化特征，并对相关文献进行了综述。
主要临床表现与其他组织学类型的喉癌无差异。然而，临床病程更具侵袭性。所有患者均接受了包括根治性手术和放疗在内的积极治疗。2例患者接受了化疗。4例患者中有2例在诊断和治疗后不久死于远处转移。
本研究对有限数量患者的研究结果支持了先前的报告，即基底样鳞状细胞癌是一种侵袭性很强的肿瘤，多见于老年人群，男性居多。相关区域及远处转移的发生率表明应进行积极治疗，并应考虑全身化疗。
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