Department of Otolaryngology - Head and Neck Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Head Neck. 2014 Feb;36(2):164-70. doi: 10.1002/hed.23286. Epub 2013 Jun 14.
Basaloid squamous cell carcinoma (BSCC) is a rare subtype squamous cell carcinoma (SCC) that frequently occurs in the larynx. BSCC is generally considered an aggressive SCC variant; however, because of its rarity, most studies are underpowered to detect statistical differences in disease-specific survival (DSS).
Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared clinicopathologic data and DSS between patients with laryngeal BSCC and SCC.
Patients with relative SCC, those with laryngeal BSCC, presented with more advanced local, regional, and distant disease (p < .001). Patients with BSCC had worse DSS, regardless of stage, tumor location within the larynx (glottis/supraglottis; p < .001), or treatment received (p ≤ .052).
Analysis of the largest laryngeal BSCC series to date (n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx.
基底样鳞状细胞癌（BSCC）是一种罕见的鳞状细胞癌（SCC）亚型，常发生于喉部。BSCC 通常被认为是一种侵袭性 SCC 变异型；然而，由于其罕见性，大多数研究在检测疾病特异性生存率（DSS）方面的统计学差异时都没有足够的效力。
我们使用监测、流行病学和最终结果（SEER）数据库，比较了喉 BSCC 和 SCC 患者的临床病理数据和 DSS。
与相对 SCC 患者相比，患有喉 BSCC 的患者表现出更晚期的局部、区域和远处疾病（p <.001）。无论分期、喉部肿瘤位置（声门/声门上；p <.001）或接受的治疗如何，BSCC 患者的 DSS 更差（p ≤.052）。
对迄今为止最大的喉 BSCC 系列（n = 145）的分析表明，BSCC 的预后比喉常规 SCC 差。
