曲安奈德给药对兔肝脏中黄素含量的影响。

Effect of triamcinolone administration on content of flavins in rabbit liver.

作者信息

Shoji S, Tsukagoshi H, Miyazawa S, Hashimoto T F

出版信息

Biochim Biophys Acta. 1976 May 28;428(3):707-10. doi: 10.1016/0304-4165(76)90201-4.

Abstract

Triamcinoline acetonide (10 mg per kg of body weight a day) was administered to rabbit fed on a laboratory chow diet. The content of flavins in liver but not in kidney, muscle and brain started to decrease 24 h after a single dose. The activities of enzymes in the liver were determined: the activities of pyruvate dehydrogenase complex, lipoamide dehydrogenase (NADH:lipoamide oxidoreductase EC 1.6.4.3), NADH dehydrogenase (NADH : (acceptor) oxidoreductase EC 1.6.99.3) and D-amino acid oxidase (D-amino acid: oxygen oxidoreductase (deaminating) EC 1.4.3.3) were decreased but those of succinate dehydrogenase (succinate : (acceptor) oxidoreductase EC 1.3.99.1) and xanthine oxidase (xanthine : oxygen oxidoreductase EC 1.2.3.2) remained unchanged. The activities of enzymes in the kidney, however, remained unchanged except the decrease in the activity of pyruvate dehydrogenase complex.

摘要

将曲安奈德（每天每千克体重10毫克）给予食用实验室标准饮食的兔子。单次给药24小时后，肝脏中黄素含量开始下降，而肾脏、肌肉和大脑中的黄素含量未下降。测定了肝脏中酶的活性：丙酮酸脱氢酶复合体、硫辛酰胺脱氢酶（NADH：硫辛酰胺氧化还原酶，EC 1.6.4.3）、NADH脱氢酶（NADH：（受体）氧化还原酶，EC 1.6.99.3）和D-氨基酸氧化酶（D-氨基酸：氧氧化还原酶（脱氨基），EC 1.4.3.3）的活性降低，但琥珀酸脱氢酶（琥珀酸：（受体）氧化还原酶，EC 1.3.99.1）和黄嘌呤氧化酶（黄嘌呤：氧氧化还原酶，EC 1.2.3.2）的活性保持不变。然而，肾脏中酶的活性除丙酮酸脱氢酶复合体活性降低外均保持不变。