Feng B, Jiang S, Yang W, Han D, Zhang S
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of PLA, Beijing 100853, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Feb;36(1):18-21.
To define the effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in guinea pigs.
The animals involved in the study were exposed to 8 Hz infrasound at 135dB SPL for 90 minutes in a reverberant chamber. The sinusoidal pendular test (SPT), auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) were respectively detected pre-exposure and at 0(within 2 hrs), 2 and 5 day after exposure. The ultrastructures of the inner ear were observed by scanning electron microscopy.
The slow-phase velocity and the frequency of the vestibular nystagmus elicited by sinusoidal pendular test (SPT) declined slightly following infrasound exposure, but the changes were not significant (P > 0.05). No differences in the ABR thresholds, the latencies and the interval peak latencies of I, III, V waves were found between the normal and the experimental groups, and among experimental groups. The amplitudes of DPOAE at any frequency declined remarkably in all experimental groups. The ultrastructures of the inner ear were damaged to different extent.
Infrasound could transiently depress the excitability of the vestibular end-organs, decrease the function of OHC in the organ of Corti and cause damage to the inner ear of guinea pigs.
明确急性次声暴露对豚鼠前庭和听觉功能以及内耳超微结构变化的影响。
将参与研究的动物置于混响室内，暴露于135dB SPL的8Hz次声中90分钟。在暴露前以及暴露后0（2小时内）、2天和5天分别检测正弦摆动试验（SPT）、听性脑干反应（ABR）和畸变产物耳声发射（DPOAE）。通过扫描电子显微镜观察内耳的超微结构。
次声暴露后，正弦摆动试验（SPT）诱发的前庭眼震慢相速度和频率略有下降，但变化不显著（P>0.05）。正常组与实验组之间以及实验组之间，ABR阈值、I、III、V波潜伏期和峰间潜伏期均无差异。所有实验组中，任一频率的DPOAE幅值均显著下降。内耳超微结构受到不同程度的损伤。
次声可短暂抑制前庭终器的兴奋性，降低柯蒂氏器外毛细胞功能，并对豚鼠内耳造成损伤。
