Zhou Xin, Liang Yong, Li Qi, Ouyang Tian-bin, Tan Man-ling
Department of Otorhinolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Apr;29(4):768-71.
To explore the characteristics of distortion product otoacoustic emission (DPOAE), auditory brainstem response (ABR) and mismatch negativity (MMN) in guinea pigs with hyperbilirubinemia and assess the impact of hyperbilirubinemia on their hearing functions.
Normal neonatal guinea pigs were randomly divided into normal control, low- and high-dose bilirubin groups. DPOAE, ABR and MMN were tested and compared between the 3 groups of guinea pigs.
The DPOAE was comparable between the 3 groups (P>0.05). The guinea pigs with peritoneal injection of low-dose bilirubin exhibited significantly prolonged wave III and V latencies and I-III interwave intervals during the ABR test in comparison with the control group (P<0.05). All the ABR parameters were significantly different between the high-dose bilirubin group and the control group (P<0.05). The detection rates of MMN were significantly different between the 3 groups (Chi(2)=7.438, P=0.024), and the average MMN latency was significantly shorter in the control group than in the high-dose group (P<0.05), but the amplitudes of MMN remained similar between the 3 groups (P>0.05).
Hyperbilirubinemia results impairment primarily of retrocochlear auditory pathway with relative mild damage of the cochlear. Apart from sensorineural auditory impairment, hyperbilirubinemia may also cause central auditory processing abnormalities.
探讨高胆红素血症豚鼠畸变产物耳声发射（DPOAE）、听性脑干反应（ABR）及失匹配负波（MMN）的特点，评估高胆红素血症对其听力功能的影响。
将正常新生豚鼠随机分为正常对照组、低剂量胆红素组和高剂量胆红素组。对3组豚鼠进行DPOAE、ABR及MMN检测并比较。
3组间DPOAE无差异（P>0.05）。腹腔注射低剂量胆红素的豚鼠在ABR检测中，与对照组相比，波Ⅲ和波Ⅴ潜伏期及Ⅰ-Ⅲ波间期显著延长（P<0.05）。高剂量胆红素组与对照组的所有ABR参数均有显著差异（P<0.05）。3组间MMN检出率有显著差异（χ²=7.438，P=0.024），对照组平均MMN潜伏期显著短于高剂量组（P<0.05），但3组间MMN波幅相似（P>0.05）。
高胆红素血症主要导致蜗后听觉通路损害，耳蜗损害相对较轻。除感音神经性听觉损害外，高胆红素血症还可能导致中枢听觉处理异常。
