Chen X, Ji T, Yang J, Zhang Z, Yao L, Deng J
Department of Otorhinolaryngology, Affiliated First Hospital, Fujian Medical University, Fuzhou 350005, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Feb;36(1):44-6.
To investigate the relationship between microvessel density and clinicopathology, as well as the prognosis in pharyngo-laryngeal malignant melanoma.
Specific endothelial cell markers with immunohistochemistry and microvessel density with morphometry in 28 cases of laryngopharyngeal malignant melanoma.
There was no correlation between the microvessel density (MVD) and the tumor size, Clark grade, as well as Breslow grade; however, significant correlation was found between the MVD and the AJC's grade, as well as the proliferating cell nuclear antigen (PCNA) labelling index. Microvessel counts were associated with overall survival by Kaplan-Meier analysis. An average vessel count of less than 36.5 (x 200) suggested a better survival, but a higher vessel count of more than 36.5 (x 200) showed a trend to worse the overall survival.
The results suggest a significant relationship between MVD and prognosis; moreover, MVD may be a useful prognostic indicator in laryngopharyngeal malignant melanoma.
探讨咽喉部恶性黑色素瘤微血管密度与临床病理特征以及预后之间的关系。
应用免疫组织化学方法检测28例喉咽恶性黑色素瘤中特异性内皮细胞标志物，并采用形态计量学方法测定微血管密度。
微血管密度（MVD）与肿瘤大小、克拉克分级以及布雷斯洛分级之间无相关性；然而，MVD与美国癌症联合委员会（AJC）分级以及增殖细胞核抗原（PCNA）标记指数之间存在显著相关性。通过Kaplan-Meier分析，微血管计数与总生存率相关。平均微血管计数小于36.5（×200）提示生存率较好，但微血管计数大于36.5（×200）则显示总生存率有变差的趋势。
结果表明MVD与预后之间存在显著关系；此外，MVD可能是喉咽恶性黑色素瘤有用的预后指标。
