Zhou B, Guan Y, Liu S, Sun J, Zhang L, Han D
Department of Otorhinolarngology, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Oct;36(5):323-5.
To report the ultrastructure of nasal mucosal cilia of Kartagener's syndrome and the operative results of 2 cases.
Both two cases were underwent endoscopic sinus surgery. Transmission and scanning electron microscopic examinations of nasal mucosa for case 1 were performed.
All 2 cases presented situs inversus, chronic paranasal sinusitis and bronchiectasis. The electron microscopic examination showed that the shape of nasal cilia and "9 + 2" structure were normal, but the lack of inner dynein arm of cilia and confused arrangement of central pair of microtubules were confirmed. The recurrent of nasal polyps after 1-year follow-up was observed in case 1.
The disturbance of mucociliary clearance due to congenital ciliary structure defect might be the cause of chronic sinusitis and polyps, which might be one of reasons for poor prognosis after operation and we should pay more close attention.
报告卡塔格内综合征鼻黏膜纤毛的超微结构及2例手术结果。
2例均行鼻内镜鼻窦手术。对病例1的鼻黏膜进行透射和扫描电子显微镜检查。
2例均表现为内脏转位、慢性鼻窦炎和支气管扩张。电子显微镜检查显示鼻纤毛形态及“9+2”结构正常，但证实存在纤毛内动力蛋白臂缺失及中央微管对排列紊乱。病例1随访1年观察到鼻息肉复发。
先天性纤毛结构缺陷导致的黏液纤毛清除功能障碍可能是慢性鼻窦炎和息肉的病因，这可能是术后预后不良的原因之一，应予以更多关注。
