Liu Z, Bu X, Xing G, Lu L
Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Aug;36(4):292-4.
To search for a hearing screening model for newborn and to investigate the prevalence of newborn hearing loss in our country.
The distortion product otoacoustic emissions (DPOAE) was used to test the hearing in 2,998 of 3,075 newborns before discharge. Otoacoustic emissions (OAE) was again used for cases failed in the hospital screening 4 weeks later. Those cases failed in both screening steps were finally tested by auditory brainstem response (ABR). All infants failed in ABR test received diagnostic evaluation audiologically to identify the category and degree of hearing loss. The pass criterion of DPOAE was defined as signal-noise-ratio (SNR) exceeding 6 dB in 4 of 5 frequencies between 1.5-6 kHz. The pass criterion of ABR was the presence of wave V in response to 35 dB nHL click stimuli.
The OAE screening in the hospital showed that 2,710 (90.4%) newborns passed the first test. Two hundred and sixty three of 288 newborns passed the second OAE screening after one month. Six of 25 infants failed in ABR test were eventually identified to be hearing impaired.
Two-stages screening, combining OAE and ABR tests, may be an ideal model for newborn hearing screening. The prevalence of congenital hearing loss is similar to that reported in the literature.
探寻新生儿听力筛查模式，并调查我国新生儿听力损失的患病率。
采用畸变产物耳声发射（DPOAE）对3075例新生儿中的2998例在出院前进行听力测试。对在医院筛查中未通过的病例，4周后再次使用耳声发射（OAE）进行检测。对在两个筛查步骤中均未通过的病例，最终采用听性脑干反应（ABR）进行检测。所有ABR测试未通过的婴儿均接受听力学诊断评估，以确定听力损失的类型和程度。DPOAE的通过标准定义为在1.5 - 6 kHz的5个频率中有4个频率的信噪比（SNR）超过6 dB。ABR的通过标准是对35 dB nHL短声刺激有V波出现。
医院内的OAE筛查显示，2710例（90.4%）新生儿通过了首次测试。288例新生儿中有263例在1个月后的第二次OAE筛查中通过。25例ABR测试未通过的婴儿中有6例最终被确定为听力受损。
结合OAE和ABR测试的两阶段筛查可能是新生儿听力筛查的理想模式。先天性听力损失的患病率与文献报道相似。
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