Tanzilli Gaetano, Barillà Francesco, Pannitteri Gaetano, Greco Cesare, Comito Cosimo, Schiariti Michele, Papalia Ugo, Mangieri Enrico
II Division of Cardiology, Institute of Heart and Great Vessels Attilio Reale, La Sapienza University, Rome, Italy.
Ital Heart J. 2003 Feb;4(2):107-12.
The hypothesis that in normotensive offspring of hypertensive parents exercise training could influence the systemic release of endothelin (ET)-1 during a provocative testing protocol was tested.
The provocative handgrip test was performed in four groups of healthy young age-matched males: offspring of hypertensive parents following a regular swimming exercise regimen (group A, n = 14); offspring of hypertensive parents and leading a sedentary lifestyle (group B, n = 11); normal volunteers with no family history of hypertension: sedentary (group C, n = 10), and following a regular swimming regimen (group D, n = 10). The plasma ET-1 was measured at baseline, after 4 min of handgrip exercise at 50% maximal capacity and following 2 (R2) and 10 (R10) min of recovery from handgrip.
ET-1 plasma levels, within the normal range in all groups at baseline (group A 0.94 +/- 0.32 pg/ml, group B 0.84 +/- 0.26 pg/ml, group C 0.78 +/- 0.35 pg/ml, group D 0.85 +/- 0.26, p = NS) showed a progressive and significant increase in group B during and after handgrip exercise (peak handgrip 1.08 +/- 0.5 pg/ml, p = NS; R2 1.35 +/- 0.36 pg/ml, p < 0.05; R10 2.76 +/- 0.75 pg/ml, p < 0.01). Significant differences were found at R2 and R10 when the ET-1 levels measured in group B were compared to those observed in group A, group C and group D. Multivariate analysis demonstrated that the serum levels of ET-1 significantly contributed to predict handgrip-induced changes when the diastolic blood pressure was the dependent variable.
Routine aerobic exercise appeared to counteract the handgrip-induced abnormal release of plasma ET-1 and may favorably affect the preclinical endothelial alterations seen in healthy offspring of hypertensive parents.
对高血压患者的血压正常的后代进行运动训练是否会在激发试验方案中影响内皮素（ET）-1的全身释放这一假设进行了测试。
对四组年龄匹配的健康年轻男性进行激发性握力试验：遵循常规游泳锻炼方案的高血压患者的后代（A组，n = 14）；有高血压家族史且久坐不动的后代（B组，n = 11）；无高血压家族史的正常志愿者：久坐不动（C组，n = 10），以及遵循常规游泳方案（D组，n = 10）。在基线时、50%最大容量握力运动4分钟后以及握力恢复2分钟（R2）和10分钟（R10）后测量血浆ET-1。
所有组在基线时ET-1血浆水平均在正常范围内（A组0.94±0.32 pg/ml，B组0.84±0.26 pg/ml，C组0.78±0.35 pg/ml，D组0.85±0.26，p =无显著差异），B组在握力运动期间及之后ET-1血浆水平呈逐渐显著升高（握力峰值1.08±0.5 pg/ml，p =无显著差异；R2 1.35±0.36 pg/ml，p < 0.05；R10 2.76±0.75 pg/ml，p < 0.01）。将B组测量的ET-1水平与A组、C组和D组观察到的水平进行比较时，在R2和R10时发现显著差异。多变量分析表明，当舒张压作为因变量时，ET-1的血清水平对预测握力引起的变化有显著贡献。
常规有氧运动似乎可以抵消握力引起的血浆ET-1异常释放，并可能对高血压患者健康后代中观察到的临床前内皮改变产生有利影响。
