烯炔与缺电子烯烃之间的选择性多米诺闭环复分解-交叉复分解反应。

Selective domino ring-closing metathesis-cross-metathesis reactions between enynes and electron-deficient alkenes.

作者信息

Royer Frédérique, Vilain Claire, Elkaïm Laurent, Grimaud Laurence

机构信息

Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France.

出版信息

Org Lett. 2003 May 29;5(11):2007-9. doi: 10.1021/ol034620r.

DOI:10.1021/ol034620r

PMID:12762708

Abstract

[reaction: see text] A selective domino ring-closing metathesis (RCM)-cross-metathesis (CM) process between enynes and electron-deficient alkenes is reported. The conditions have been optimized for enynes 3 and methyl acrylate with catalyst IV. The scope and limitations of this reaction are described, and a possible mechanism is discussed.

摘要

[反应：见正文] 报道了烯炔与缺电子烯烃之间的选择性多米诺环化复分解（RCM）-交叉复分解（CM）过程。已针对烯炔3和丙烯酸甲酯与催化剂IV对反应条件进行了优化。描述了该反应的适用范围和局限性，并讨论了可能的反应机理。