来自绒毛菊的倍半萜内酯。

Sesquiterpene lactones from Lychnophora ericoides.

作者信息

Sakamoto Humberto T, Flausino Douglas, Castellano Eduardo E, Stark Christian B W, Gates Paul J, Lopes Norberto P

机构信息

Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, CEP 14.040-903, Brazil.

出版信息

J Nat Prod. 2003 May;66(5):693-5. doi: 10.1021/np020314v.

DOI:10.1021/np020314v

PMID:12762810

Abstract

Two new sesquiterpene lactones, (4S,6R,7S,8S,10R,11S,16R)-1-oxo-3(10),8(16)-diepoxy-16-methylprop-1Z-enyl-16-methoxygermacra-2-en-6(12)-olide (1) and (4S,6R,7S,8S,10R,11S)-1-oxo-3,10-epoxy-8-angeloyloxygermacra-2-en-6(12)-olide (2), were isolated from Lychnophora ericoides. Their structures, including absolute configuration, were established by spectroscopic methods, including single-crystal X-ray analysis. Monitoring the furanoheliangolide metabolism of L. ericoides revealed an increase in biosynthesis during the plant flowering period.

摘要

从毛丝花（Lychnophora ericoides）中分离出两种新的倍半萜内酯，即(4S,6R,7S,8S,10R,11S,16R)-1-氧代-3(10),8(16)-二环氧-16-甲基丙-1Z-烯基-16-甲氧基吉马烯-2-烯-6(12)-内酯（1）和(4S,6R,7S,8S,10R,11S)-1-氧代-3,10-环氧-8-当归酰氧基吉马烯-2-烯-6(12)-内酯（2）。通过包括单晶X射线分析在内的光谱方法确定了它们的结构，包括绝对构型。对毛丝花的呋喃海良内酯代谢进行监测发现，在植物开花期生物合成有所增加。