Chaperon F, Tricklebank M D, Unger L, Neijt H C
Nervous System Research, Novartis Pharma AG, S-386.3.32, Postfach, CH-4002, Basel, Switzerland.
Neuropharmacology. 2003 Jun;44(8):1047-53. doi: 10.1016/s0028-3908(03)00113-8.
The dopamine D(3) receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D(3) and D(4) receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390, a selective D(1) receptor antagonist, and by L-741,626, a selective D(2) receptor antagonist. Moreover, the selective D(2) receptor agonist trihydroxy-N-n-propylnoraporphine (TNPA) elicited a robust hypothermia which was prevented by pretreatment with L-741,626 but not by A-437203. In agreement with previous data obtained in D(3) knock-out mice, present results suggest that D(2) rather than D(3) receptors mediate dopamine receptor agonist-induced hypothermia in rats. In addition, it appears that both D(1) and D(2) receptors may be involved in a cooperative manner.
多巴胺D(3)受体激动剂PD 128907可降低大鼠体温。选择性多巴胺D(3)和D(4)受体拮抗剂A-437203和L-745870分别不能阻止这种作用。相反，PD 128907诱导的体温过低被选择性D(1)受体拮抗剂SCH 23390和选择性D(2)受体拮抗剂L-741626拮抗。此外，选择性D(2)受体激动剂三羟基-N-正丙基去甲阿朴啡（TNPA）引起强烈的体温过低，L-741626预处理可阻止这种情况，但A-437203不能。与先前在D(3)基因敲除小鼠中获得的数据一致，目前的结果表明，在大鼠中，介导多巴胺受体激动剂诱导体温过低的是D(2)受体而非D(3)受体。此外，似乎D(1)和D(2)受体可能以协同方式参与其中。
