Salmi P, Jimenez P, Ahlenius S
Department of Psychology, University of Stockholm, Sweden.
Eur J Pharmacol. 1993 Jun 4;236(3):395-400. doi: 10.1016/0014-2999(93)90477-y.
Administration of the selective dopamine D1 and D2 receptor agonists, A 68930 (0.9-60.0 mumol kg-1 s.c.) and quinpirole (0.1-6.0 mumol kg-1 s.c.), produced a dose-dependent decrease in core temperature in the rat. The hypothermia induced by quinpirole (1.5 mumol kg-1) was antagonized by pretreatment with the selective dopamine D2 receptor antagonist, raclopride (1.6 mumol kg-1 s.c.), but not by the dopamine D1 receptor antagonist, SCH 23390 (0.3 mumol kg-1 s.c.), whereas the hypothermia induced by A 68930 (3.8 mumol kg-1) was antagonized by SCH 23390 (0.3 mumol kg-1), but not by raclopride (1.6 mumol kg-1). Together, these results suggest that both dopamine D1 and D2 receptors are specifically involved in the regulation of body temperature in the rat.
给予选择性多巴胺D1和D2受体激动剂A 68930（0.9 - 60.0 μmol/kg皮下注射）和喹吡罗（0.1 - 6.0 μmol/kg皮下注射）后，大鼠的核心体温出现剂量依赖性下降。喹吡罗（1.5 μmol/kg）诱导的体温过低可被选择性多巴胺D2受体拮抗剂雷氯必利（1.6 μmol/kg皮下注射）预处理拮抗，但不能被多巴胺D1受体拮抗剂SCH 23390（0.3 μmol/kg皮下注射）拮抗；而A 68930（3.8 μmol/kg）诱导的体温过低可被SCH 23390（0.3 μmol/kg）拮抗，但不能被雷氯必利（1.6 μmol/kg）拮抗。这些结果共同表明，多巴胺D1和D2受体均特异性参与大鼠体温的调节。
