尼古丁和α-银环蛇毒素会改变发育中雏鸡顶盖中胆碱能感受神经元的树突生长。

Nicotine and alpha-bungarotoxin modify the dendritic growth of cholinoceptive neurons in the developing chick tectum.

作者信息

Torrão Andréa S, Lindstrom Jon M, Britto Luiz R G

机构信息

Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 São Paulo, S.P., Brazil.

出版信息

Brain Res Dev Brain Res. 2003 Jun 12;143(1):115-8. doi: 10.1016/s0165-3806(03)00109-3.

DOI:10.1016/s0165-3806(03)00109-3

PMID:12763587

Abstract

Nicotinic acetylcholine receptors have been suggested to participate in morphogenetic processes during development of the nervous system. In this study, nicotine applied both in ovo and in vitro produced a reduction of the neuritic length of cholinoceptive neurons of the developing chick tectum, whereas alpha-bungarotoxin produced the opposite effect. Taken together with previous data, our results are indicative of a role of the alpha-bungarotoxin-sensitive nicotinic receptors in neural development.

摘要

烟碱型乙酰胆碱受体已被认为参与神经系统发育过程中的形态发生过程。在本研究中，在鸡胚内和体外应用尼古丁均导致发育中的鸡视顶盖胆碱能感受神经元的神经突长度缩短，而α-银环蛇毒素则产生相反的效果。结合先前的数据，我们的结果表明α-银环蛇毒素敏感的烟碱型受体在神经发育中起作用。