FXYD7，钠钾ATP酶的首个脑及亚型特异性调节因子：其翻译后修饰的生物合成与功能
FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications.
作者信息
Crambert Gilles, Béguin Pascal, Uldry Marc, Monnet-Tschudi Florianne, Horisberger Jean-Daniel, Garty Haim, Geering Käthi
机构信息
Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland.
出版信息
Ann N Y Acad Sci. 2003 Apr;986:444-8. doi: 10.1111/j.1749-6632.2003.tb07227.x.
The FXYD protein family has recently been defined as a result of the search for homologues of the Na,K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. FXYD7 has been seen to have a role as a brain- and isozyme-specific regulator of Na/K-ATPase. In this study, the biosynthesis, membrane topology, nature, and role of the processing of FXYD7 are investigated.
FXYD蛋白家族最近是在EST和基因数据库中搜索钠钾ATP酶γ亚基、CHIF和磷膜蛋白的同源物时被定义的。FXYD7被认为是钠钾ATP酶的一种脑和同工酶特异性调节剂。在本研究中，对FXYD7的生物合成、膜拓扑结构、性质及加工作用进行了研究。
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