Bakulin V S, Bol'shakova T D, Bunatian A F, Menshikov V V, Sudakov K V
Biull Eksp Biol Med. 1976;81(4):399-402.
Continuous many-hour stimulation of the hypothalamic negative emotiogenic centres (ventromedial nuclei) evoked a stable arterial hypertension with a peculiar phasic dynamics of the adrenal secretory activity in waking immobilized rabbits. Bilateral extirpation of the adrenal glands decreased the initial level of the average arterial pressure, inhibiting development of stable arterial hypertension. Many-hour stimulation of the mentioned structures also produced stable arterial hypertension in adrenalectomized rabbits if preceded by the administration of hydrocortisone together with adrenaline. Against the background of separate administration of hydrocortisone and adrenaline to adrenalectomized rabbits, many-hour stimulation of the ventromedial hypothalamus evoked a short-term rise in the arterial pressure. A conclusion was drawn that activation of hormones of the adrenal cortical and medullary layers played an important part in the formation of stable arterial hypertension in rabbits under continuous many-hour stimulation of the hypothalamic negative emotiogenic centres.
在清醒的固定家兔中，连续数小时刺激下丘脑负性情绪发生中枢（腹内侧核）可诱发稳定的动脉高血压，并伴有肾上腺分泌活动的特殊阶段性动态变化。双侧肾上腺切除可降低平均动脉压的初始水平，抑制稳定动脉高血压的发展。如果在给肾上腺切除的家兔注射氢化可的松和肾上腺素之后，对上述结构进行数小时刺激，也可使其产生稳定的动脉高血压。在给肾上腺切除的家兔分别注射氢化可的松和肾上腺素的背景下，对腹内侧下丘脑进行数小时刺激会引起动脉压短期升高。得出的结论是，在连续数小时刺激下丘脑负性情绪发生中枢的情况下，肾上腺皮质和髓质层激素的激活在家兔稳定动脉高血压的形成中起重要作用。
